Author's response to reviews Title: Microenvironment Alters Epigenetic and Gene Expression Profiles in Swarm Rat Chondrosarcoma Tumors Authors:

Author's response to reviews Title: BMP and TGFbeta Pathways in Human Central Chondrosarcoma: Enhanced Endoglin and Smad 1 Signaling in High Grade Tumors Authors:

Author's response to reviews Title: The antiapoptotic gene survivin is highly expressed in human chondrosarcoma and promotes drug resistance in chondrosarcoma cells in vitro Authors:

Author's response to reviews Title: Regulation of sonic hedgehog-GLI1 downstream target genes PTCH1, Cyclin D2, Plakoglobin, PAX6 and NKX2.2 and their epigenetic status in major brain tumors Authors:

Author's response to reviews Title: Gross genomic alterations and gene expression profiles of high- grade serous carcinoma of the ovary with and without BRCA1 inactivation Authors:

Title: Gross genomic alterations and gene expression profiles of high-grade serous carcinoma of the ovary with and without BRCA1 inactivation Authors: Manohar Pradhan ([email protected]) Björn Å Risberg1 ([email protected]) Claes G Tropé ([email protected]) Matt van de Rijn ([email protected])

Comprehensive Gene Expression Characterization of Theswarm Rat Chondrosarcoma

Introduction Chondrosarcoma is the second most common type of skeletal malignancy. Current treatment protocols are based primarily on surgical resection since its response to chemotherapy and radiotherapy is very poor. Survival rates for grade III tumors are only 29%. A better understanding of its biology is necessary for the design of new therapeutic modalities that could improve survival rate...